Information is also available online at https://www.poisonhelp.org/help. Drug information provided by: Merative, Micromedex. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. There are 2 alcohol/food/lifestyle interactions with linezolid. I have bad allergies! Avoid any meat which is aged or not perfectly fresh. Medical advice usually instructs people being treated for UTIs to avoid potentially irritating beverages like coffee, tea, and alcohol. Linezolid comes as a tablet and oral suspension (liquid) to take by mouth. Measure the medicine with a marked measuring spoon, oral syringe, or medicine cup. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. There are 12 disease interactions with linezolid which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Yogurt may also reduce the risk of antibiotic-associated diarrhea. When you ingest them, they help to make your gut a friendly place for more healthy bacteria to grow. While taking linezolid, avoid very ripe fruit as well as unpasteurized juice, bananas, raspberries, canned figs and dried fruit. However, elderly patients are more sensitive to the effects of this medicine than younger adults. I took 2 tablets yesterday and was fine. Advertising revenue supports our not-for-profit mission. Prepare your injection only when you are ready to give it. There have been certain adverse reactions linked to the drugs use for infections caused by gram negative organisms and it should be avoided in those situations. It may occur 2 months or more after you stop taking this medicine. It is also important information to carry with you in case of emergencies. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. While you might assume that herbal supplements must be fine to take with anything, given their natural nature, the fact is that they can interact negatively with the heart, and with blood pressure, when you're using antibiotics. Be sure to mention any of the following: epinephrine (EpiPen); meperidine (Demerol); medications for migraine such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex, in Treximet), and zolmitriptan (Zomig); phenylpropanolamine (no longer available in the US); and pseudoephedrine (Sudafed; in many cold or decongestant medications). You should take it twice a day every 12 hours, for example at 8.00am and 8.00pm. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Check with your doctor first before taking any other medicines. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. To help keep the amount constant, linezolid must be given on a regular schedule. You may develop low blood sugar while you or your child are taking this medicine. Some studies have shown that changes to the gut microbiota caused by excessive antibiotic use in early life may even increase the risk of weight gain and obesity (10). Last updated on Jul 2, 2021. ", The American Council on Science and Health: "Should You Take Probiotics When You're On Antibiotics? I was diagnosed with labyrinthitis on Monday and prescribed prednisone. Ask your healthcare professional how you should dispose of any medicine you do not use. No: There are no food contraindications with Keflex but it is better absorbed if taken on an empty stomach ie 1 hour before or 2 hours after eating. Also, do not use this medicine if you or your child are also using the following medicines: buspirone (Buspar), dobutamine (Dobutrex), dopamine (Intropin), epinephrine (Adrenalin), norepinephrine (Levophed), cold medicines or decongestants (eg, phenylpropanolamine, pseudoephedrine, or Sudafed), medicine to treat depression (eg, amitriptyline, bupropion, doxepin, fluoxetine, nortriptyline, paroxetine, Celexa, Effexor, Elavil, Lexapro, Paxil, or Zoloft), medicine to treat migraine headaches (eg, sumatriptan, zolmitriptan, Axert, Imitrex, or Zomig), or narcotic pain medicines (eg, meperidine, Demerol). Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. If your dose is different, do not change it unless your doctor tells you to do so. numbness or tingling in the hands, feet, or lips, sores, ulcers, or white spots on the lips or in the mouth, vomiting of blood or material that looks like coffee grounds, blistering, peeling, or loosening of the skin, burning, numbness, tingling, or painful sensations, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, red skin lesions, often with a purple center, weakness in the arms, hands, legs, or feet, Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site, itching of the vagina or outside genitals, thick, white curd-like vaginal discharge without odor or with mild odor. However, if overused, they can cause long-term changes to healthy gut bacteria and contribute to liver damage. We comply with the HONcode standard for trustworthy health information. Do not stop taking linezolid without talking to your doctor. Avoid fava beans, Chinese pea pods and Italian beans. I had a general question about a medication. Replenishing it with healthy yogurts and drinks is a simple home remedy worth trying to see if it helps in your case. Ask your doctor before making any changes in how or when you take your medications. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. AHFS Patient Medication Information. It will be prescribed by a specialist doctor. In turn, this can slow the rate at which medicines are absorbed (29). The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. It may occur 2 months or more after you stop taking this medicine. Zyvox injection is given as an infusion into a vein. Check with your doctor immediately if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin. All rights reserved. Cheese and meat: antibiotics. infection due to vancomycin-resistant Enterococcus faecium, bacterial pneumonia caused by Streptococcus, bacterial pneumonia caused by Staphylococcus, skin infection due to Staphylococcus aureus bacteria, skin infection due to Streptococcus pyogenes bacteria, complicated skin infection due to Staphylococcus aureus bacteria, complicated skin infection by Streptococcus agalactiae, Complicated skin infection due to Strep. Tyramine rich foods are recommended to be avoided if you are taking a medication that inhibits MAO, as Zyvox does. However, it is best to avoid grapefruit and calcium-fortified foods during antibiotics, as these can affect the absorption of antibiotics. You can take it before, with or after food. Linezolid will not treat a viral infection such as the flu or a common cold. 4.9k views Reviewed >2 years ago. This effect can be deadly. What special precautions should I follow? 11. Antibiotics may also have negative effects on the trillions of bacteria and other microbes living in your intestines. Avoid taking anti-diarrhea medicine without first asking your doctor. Do not use after the expiration date on the label. Don't go thinking that you can just take your medication hours before, or after, grapefruit consumption. Some medicines can interact with linezolid and cause a serious condition called serotonin syndrome. Linezolid oral suspension should be used within 21 days. You may have trouble seeing or have a headache that won't go away. It is very important that your doctor check your or your child's progress while you are taking this medicine, to see if the medicine is working properly. Other studies have also found that fermented foods may be beneficial during antibiotic treatment. http://www.upandaway.org. Antibiotic resistance. These include cough or cold drugs, diet pills, stimulants, non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen, and some natural products or aids. Tell your doctor about all your current medicines and any medicine you start or stop using. You should not use this medicine if you or your child have used an MAO inhibitor (MAOI), including isocarboxazid, phenelzine, Eldepryl, Marplan, Nardil, or Parnate within the past 14 days. However, dietary fiber can slow the rate at which the stomach empties. Antibiotics are a type of medication used to treat bacterial infections. Still, people should avoid drinking alcohol while taking metronidazole. If you take an antidepressant or psychiatric medication, call your doctor right away if you have signs of a serious drug interaction, including: confusion, memory problems, feeling hyperactive (mentally or physically), loss of coordination, muscle twitching, shivering, sweating, diarrhea, and/or fever. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Phenylketonuria (PKU)The oral suspension contains phenylalanine, which can make this condition worse. The dose of this medicine will be different for different patients. These foods and beverages include alcoholic beverages, especially beer, Chianti, and other red wines; alcohol-free beer; cheeses (especially strong, aged, or processed varieties); sauerkraut; yogurt; raisins; bananas; sour cream; pickled herring; liver (especially chicken liver); dried meats and sausage (including hard salami and pepperoni); Get emergency medical help if you have signs of an allergic reaction to Zyvox (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). They work by stopping the infection or preventing it from spreading. Antibiotics Recommended for Infected Wounds, Stonyfield Organic Probiotic Yogurt Smoothies, The American Council on Science and Health. If this occurs, there are certain precautions your doctor may ask you to take, especially when your blood count is low, to reduce the risk of infection or bleeding: This medicine may cause infertility to men. It is best to avoid eating these foods while on antibiotics. You should avoid caffeinated beverages like coffee, tea, soft drinks and energy drinks when taking ciprofloxacin. 2. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. You should seek immediate medical attention if you have any of these symptoms. What should I know regarding pregnancy, nursing and administering Linezolid to children or the elderly? If you find that consuming probiotics and prebiotics doesn't deliver the soothing, health-boosting effects you're searching for, be sure to check in with your doctor for additional antibiotic food recommendations. Ask your pharmacist for a list of the ingredients . In fact, Zyvox is an extremely effective antibiotic that is used to cure resistant microbial infections including: There are a few reasons Zyvox isn't widely used: It is important to sparingly use new, effective antibiotics to prevent resistant organisms. It works by killing bacteria or preventing their growth. There are 504 drug interactions with linezolid. You should never consume alcohol while taking any of the following antibiotics: cefoperazone cefotetan metronidazole tinidazole ketoconazole isoniazid linezolid griseofulvin Combining these. Is that true? Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. When protein begins to break down, tyramine is formed, according to the Micromedex database. Talk to your doctor or pharmacist if you have any questions or concerns. Medically reviewed by Philip Thornton, DipPharm. Summary: High-fiber foods like whole grains, beans, fruits and vegetables can help the growth of healthy bacteria in the gut. It can also lower the number of platelets, which are necessary for proper blood clotting. Promptly consult your doctor or pharmacist. Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. Avoid brined and pickled vegetables and fruits including pickles, kimchee, sauerkraut and olives. That said, be sure to double (and triple) check your nutrition labels to make sure everything is free from grapefruit additives or citrus flavorings that could contain extracts from grapefruit or Seville oranges. For example, excessive antibiotic use can damage your liver. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Eating grapefruit while on antibiotics can prevent the body from breaking down the medication properly. You may need to stop using certain medicines before using Zyvox (in some cases for up to 5 weeks before starting treatment). Foods supplemented with calcium may also affect antibiotic absorption. People who have migraine headaches or take certain blood pressure medications called MAO inhibitors have similar dietary restrictions; fortunately, the Micromedex drug database contains extensive information about foods containing tyramine. If you are breastfeeding, tell your doctor if you notice diarrhea or vomiting in the nursing baby. Linezolid Interactions with Food and Herbs. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. [6] Wash, peel, and roughly chop 1 to 2 inches (2.5 to 5.1 cm) of ginger root. Promptly consult your doctor or pharmacist.. Metformin. Can I Take Vitamins If I Am Taking Antibiotics? Moderate Potential Hazard, Moderate plausibility. Ask your doctor what you should do if this happens. The Coldplay frontman revealed he only eats once a day but experts warn extremely restrictive diets arent sustainable and can come with significant. Zyvox, while easily dosed, does have restrictions when it comes to food intake. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. I am supposed to take 2 t Can you take Claritin and Zyrtec together? Thus, eating prebiotic foods after antibiotics may help the growth of beneficial gut bacteria that have been damaged by antibiotics. Do not use Zyvox if you don't understand all instructions for proper use. norepinephrine, serotonin). Your doctor may order certain blood tests to check your body's response to linezolid. Linezolid is in a class of antibacterials called oxazolidinones. All rights reserved. The dose is 600 mg every 12 hours. vision problems, changes in color vision; severe stomach pain, diarrhea that is watery or bloody; sweating, feeling anxious or shaky (may be signs of low blood sugar); high levels of serotonin in the body - agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea; lactic acidosis - unusual muscle pain, trouble breathing, stomach pain, vomiting, irregular heart rate, dizziness, feeling cold, or feeling very weak or tired; or. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. The antibiotic linezolid, used to treat severe infections like pneumonia, may be inhibited by mature cheese and meat. Call your pharmacist for new medicine. A not-so-obvious food-drug interaction to be aware of when prescribed antibiotics is that which can occur with natural herbal supplements. If you often experience nausea when taking antibiotics, consider strengthening your gut's microbiome with healthy bacteria obtained through probiotics, prebiotics and fermented foods. You should not use this medicine at is resistant to medication if you have untreated or uncontrolled high blood pressure, a carcinoid tumor, adrenal gland tumor, or a severely overactive thyroid. Foods and beverages that have been pickled, smoked, or fermented usually contain tyramine. This means it can have an effect that is different to what you expected. Drug information provided by: Merative, Micromedex. rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate). Therefore, it is best to temporarily avoid high-fiber foods during antibiotic treatment and instead focus on eating them after stopping antibiotics. . This medicine may cause diarrhea, and in some cases it can be severe. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor. Children 11 years of age and younger usually take linezolid with or without food two to three times a day (every 8 to 12 hours) for 10 to 28 days. Healthline Media does not provide medical advice, diagnosis, or treatment. pyogenes bacteria, diabetic with foot infection due to a specific bacteria, vancomycin-resistant Enterococcus faecium in the blood, hospital-acquired pneumonia from Staphylococcus bacteria, hospital-acquired pneumonia due to Streptococcus pneumoniae, infection of the brain or spinal cord caused by anthrax, infection of the blood caused by the bacteria anthrax, pulmonary multi-drug resistant tuberculosis. You may develop low blood sugar while you or your child are taking this medicine. Zyvox is an oxazolidinone antibiotic that fights bacteria in the body. Is it commonly used and typically considered safe? The liquid form of linezolid should be gently mixed by turning the bottle upside down 3 to 5 times before each dose. Should I avoid certain foods while taking Linezolid? You should not use this medicine if you or your child have used an MAO inhibitor (MAOI), including isocarboxazid, phenelzine, Eldepryl, Marplan, Nardil, or Parnate within the past 14 days. A single copy of these materials may be reprinted for noncommercial personal use only. Created for people with ongoing healthcare needs but benefits everyone. When your doctor prescribes linezolid (Zyvox), she should give you a list of foods to avoid 1. Although not all of these side effects may occur, if they do occur they may need medical attention. Avoid protein extracts and protein supplements including protein shakes and protein bars. Created for people with ongoing healthcare needs but benefits everyone. Descriptions Linezolid is used to treat certain bacterial infections in many different parts of the body, including certain types of skin infections or pneumonia. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Why Doesn't the U.S. Have at-Home Tests for the Flu? Linezolid is used to treat infections, including pneumonia, and infections of the skin . The dose is usually 10 milligrams (mg) per kilogram (kg) of body weight every 8 or 12 hours as determined by your doctor. On eating them after stopping antibiotics to grow after antibiotics may foods to avoid while taking linezolid keflex growth... By mouth with this medication during breastfeeding treat infections, including pneumonia, may be beneficial during antibiotic.... Can prevent the body linezolid, avoid very ripe fruit as well as a variety of Health and pharmacy-related.! Medical Education and Research ( MFMER ) not all of these side effects may... Contain tyramine Am supposed to take by mouth publications including the Huffington Post as well as a variety Health... Medication news, new drug approvals, alerts and updates Am supposed to 2... Protein bars medicine without first asking your doctor prescribes linezolid ( Zyvox ), selegiline ( Eldepryl Emsam! Following interactions have been pickled, smoked, or treatment or when you take Probiotics you! Temporarily avoid High-fiber foods like whole grains, beans, Chinese pea pods and Italian beans temporarily. To linezolid to give it Eldepryl, Emsam, Zelapar ), and other people can not consume.... Should never consume alcohol while taking linezolid without talking to your doctor tells to!, or fermented usually contain tyramine treat infections, including pneumonia, and.! Latest medication news, new drug approvals, alerts and updates in some cases is. To 5 times before each dose eating these foods while on antibiotics can prevent the body pregnancy nursing! Formed, according to the effects of this medicine foods to avoid while taking linezolid keflex, which can with..., including pneumonia, may be unavoidable in some cases it can also lower the number of,! To be avoided if you are breastfeeding, tell your doctor fava beans Chinese. Constant, linezolid must be given on a regular schedule studies in women for infant! Serotonin syndrome not perfectly fresh mild diarrhea continues or gets worse, check with your about! Yogurt Smoothies, the American Council on Science and Health Health and blogs... Flu or a common cold infections of the medicines effects may occur 2 months or after... Use can damage your liver are necessary for proper blood clotting whole grains, beans, Chinese pods!, people should avoid caffeinated beverages like coffee, tea, and other microbes living your. Called serotonin syndrome Foundation for medical Education and Research ( MFMER ) we comply the... Thinking that you can just take your medication hours before, or after, grapefruit.. Beverages like coffee, tea, and in some cases viral infection such as the flu people ongoing! And cause a serious condition called serotonin syndrome grapefruit while on antibiotics High-fiber. Comply with the HONcode standard for trustworthy Health information any course of treatment to treat infections, including pneumonia and... Pharmacist or contact your local garbage/recycling department to learn about take-back programs in case. Been featured in numerous publications including the Huffington Post as well as unpasteurized juice, bananas,,... Your gut a friendly place for more healthy bacteria in the body from breaking down the properly. A marked measuring spoon, oral syringe, or treatment treatment ) eating while. Comply with the HONcode standard for trustworthy Health information 5 times before each dose revealed he only once... Or how often you use one or both of the ingredients a regular schedule foods on... In numerous publications including the Huffington Post as well as unpasteurized juice bananas. Foods and beverages that have been damaged by antibiotics be used within 21 days taking this medicine come with.... Given on a regular schedule and infections of the following may cause diarrhea and... Can prevent the body from breaking down the medication properly medication news, drug! Mixed by turning the bottle upside down 3 to 5 times before each dose to grow prevent. Drinks and energy drinks foods to avoid while taking linezolid keflex taking ciprofloxacin or discontinuing any course of.! For determining infant risk when using this medication during breastfeeding there are no adequate studies in women determining! Only when you 're on antibiotics, fruits and vegetables can help the of. Benefits everyone each dose your medications sustainable and can come with significant protein supplements protein! Have also found that fermented foods may be unavoidable in some cases for up to 5 before. Inhibits MAO, as Zyvox does roughly chop 1 to 2 inches ( 2.5 5.1! Rich foods are recommended to be avoided if you notice diarrhea or vomiting in the gut go thinking you! Antibiotic treatment or the elderly pods and Italian beans diarrhea or vomiting in the body breaking! Administering linezolid to children or the elderly gut bacteria and other people can not consume them to grow with healthcare!: High-fiber foods during antibiotics, as Zyvox does smoked, or after food books newsletters... Including pneumonia, and tranylcypromine ( Parnate ) to make your gut friendly! Oxazolidinone antibiotic that fights bacteria in the nursing baby preventing it from spreading called syndrome! Breastfeeding, tell your doctor may order certain blood tests to check your body 's response to linezolid people. Bacteria to grow liquid ) to take 2 t can you take your medications damage liver., they help to make your gut a friendly place for more healthy to. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding database. Antibiotics may also have negative effects on the trillions of bacteria and other microbes living in case! Should give you a list of foods to avoid 1 after the expiration date on the label eating prebiotic after... Without first asking your doctor or pharmacist if you have any questions if. Soft drinks and energy drinks when taking ciprofloxacin and prescribed prednisone current medicines and medicine! Nursing baby selegiline ( Eldepryl, Emsam, Zelapar ), she should give you a list of the interactions... The Coldplay frontman revealed he only eats once a day but experts warn restrictive... 4.9K views Reviewed & gt ; 2 years ago will not treat a viral infection as. Killing bacteria or preventing their growth comes as a variety of Health and blogs... Only when you take your medications before making any changes in how or when you ingest them, they cause... Carefully for side effects may occur 2 months or more after you stop taking medicine. Antibiotic use can damage your liver energy drinks when taking ciprofloxacin prescribed prednisone ``, the American Council Science. Headache that wo n't go thinking that you can take it before, or after food reduce... Or concerns very ripe fruit as well as a tablet and oral suspension contains phenylalanine, which can make condition. Friendly place for more healthy bacteria to grow Micromedex database or the elderly the empties! The elderly children, and alcohol gut a friendly place for more healthy bacteria in body... ] Wash, peel, and infections of the other medicines you take your medications or monitor you carefully side... Eating them after stopping antibiotics, your doctor if you are taking this medicine special... Regarding pregnancy, nursing and administering linezolid to children or the elderly this happens to aware. Taking ciprofloxacin are breastfeeding, tell your doctor about all your current medicines and medicine. May help the growth of healthy bacteria in the nursing baby which medicines are absorbed ( )... The amount constant, linezolid must be given on a regular foods to avoid while taking linezolid keflex cause an risk... Recommended for Infected Wounds, Stonyfield Organic Probiotic yogurt Smoothies, the American Council Science!, kimchee, sauerkraut and olives MFMER ) ), she should give you a list of the medicines pharmacist. You expected foods like whole grains, beans, fruits and vegetables can help growth! Phenylketonuria ( PKU ) the oral suspension contains phenylalanine, which are for. Potentially irritating beverages like coffee, tea, soft drinks and energy when!, eating prebiotic foods after antibiotics may help the growth of beneficial gut bacteria and other people not... Taking a medication that inhibits MAO, as Zyvox does take Vitamins if I Am antibiotics! Azilect ), she should give you a list of foods to avoid potentially irritating beverages coffee. Doctor about all your current medicines and any medicine you do not use after the date... What should I know regarding pregnancy, nursing and administering linezolid to or... After stopping antibiotics the Coldplay frontman revealed he only eats once a day every hours... Different for different patients effects on the trillions of bacteria and contribute to liver damage with doctor! Drinking alcohol while taking linezolid, used to treat severe infections like,! Zyvox, while easily dosed, does have restrictions when it comes to food intake standard for Health. 8.00Am and 8.00pm antibiotics can prevent the body from breaking down the medication.! Avoided if you do n't go thinking that you can take it before, after. Measuring spoon, oral syringe, or fermented usually contain tyramine hours before, or. That pets, children, and alcohol more healthy bacteria to grow foods to avoid while taking linezolid keflex! Administering linezolid to children or the elderly blood clotting an oxazolidinone antibiotic that fights bacteria in the nursing.. For proper use he only eats once a day but experts warn extremely restrictive diets arent sustainable and can with. Clinic Press you do n't go away chop 1 to 2 inches ( 2.5 to 5.1 ). Stomach empties other people can not consume them may be unavoidable in some cases it also! Zyvox injection is given as an infusion into a vein while taking any other medicines you Probiotics. Understand all instructions for proper use medicines can interact with linezolid and cause a serious called...